Created by LAI Corporation based on the design data of the YF-24 Evolution, the "Prophecy" was named to signify its role in leading the development of more advanced fighters. Before the combat-proof testing of the VF-25F Messiah, several YF-25 test beds were produced to examine the fighter's mechanisms and performance, along with EG-01M/MP EX-Gear control tests. The 001-type was tested on the planet Messiah 025 by Angers 672, a Meltrandi warrior known for her strong resistance to high G-forces. Following this, the unit saw use aboard the Macross Quarter of the Strategic Military Services (S.M.S.) Frontier fleet branch.
The YF-25 was also showcased during the Vanquish races' Starry Cup event on the resort ship Evena of the Macross Galaxy fleet. However, it was attacked by the anti-New United Nations Government organization Fasces and damaged by racer Chelsea Scarlett. After the attack, the damaged parts were repaired, and the unit was used in the battle against Fasces. The head unit was remodeled with parts from the VF-19ACTIVE Nothung. The AI control "Brünnhilde" was ported from the VF-19 ACTIVE for the fighter's onboard computer and updated. Chelsea was chosen to pilot the fighter, with her personal mark drawn and its legs painted white.
During the final battle, the fighter was deployed and equipped with the "SPS-25P / MF25 Paladin Pack," a heavy armor assault pack originally developed to combat the Vajra.