Astro Boy is a science fiction series set in a futuristic world where robots co-exist with humans. Its focus is on the adventures of the titular "Astro Boy" (sometimes called simply "Astro"): a powerful android created by the head of the Ministry of Science, Doctor Tenma. Dr. Tenma created Astro to replace his son Tobio, who was killed in a car accident. Dr. Tenma built and adopted Astro in Tobio's memory and treated Astro as lovingly as if he was the real Tobio. However, Dr. Tenma soon realized that the little android could not fill the void of his lost son, especially given that Astro could not grow older or express human aesthetics. In the original 1960 edition, Tenma rejected Astro and sold him to a cruel circus owner, Hamegg. In the 1980 edition, Hamegg kidnapped Astro while Tenma was trying to find him. In the 2009 film, Tenma rejected Astro simply because he could not stop thinking about Toby, but later during the film, Tenma realized that Astro made credit to replace Tobio; as a result, Tenma decided that he would readopt Astro. None of these events about Astro being rejected (completely or temporarily) or kidnapped in both the 1960 and 1980 cartoons as well as in the 2009 film happened in the 2003 cartoon as Astro's birth was given by Professor Ochanomizu.
After some time, Professor Ochanomizu, the new head of the Ministry of Science, notices Astro Boy performing in the circus and convinces Hamegg to turn Astro over to him. He then takes Astro in as his own and treats him gently and warmly, becoming his legal guardian. He soon realizes that Astro has superior powers and skills, as well as the ability to experience human emotions.
Astro then is shown fighting crime, evil, and injustice using his seven powers: 100K horsepower strength, jet flight, high intensity lights in his eyes, adjustable hearing, instant language translation, a retractable machine gun in his hips, and a high IQ capable of determining if a person is good or evil. Most of his enemies are robot-hating humans, robots gone berserk, or alien invaders. Almost every story includes a battle involving Astro and other robots. In one manga episode, Astro takes on the US Air Force, and stops it from bombing some innocent Vietnamese villagers (this was a time-travel episode, in which Astro went back from the 21st century to 1969).